BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study
Identifieur interne : 002B47 ( Main/Exploration ); précédent : 002B46; suivant : 002B48BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study
Auteurs : S. Karamohamed [États-Unis] ; J. C. Latourelle [États-Unis] ; B. A. Racette [États-Unis] ; J. S. Perlmutter [États-Unis] ; G. F. Wooten [États-Unis] ; M. Lew [États-Unis] ; C. Klein [Allemagne] ; H. Shill [États-Unis] ; L. I. Golbe [États-Unis] ; M. H. Mark [États-Unis] ; M. Guttman [Canada] ; G. Nicholson [Australie] ; J. B. Wilk [États-Unis] ; M. Saint-Hilaire [États-Unis] ; A. L. Destefano [États-Unis] ; R. Prakash [États-Unis] ; S. Tobin [États-Unis] ; J. Williamson [États-Unis] ; O. Suchowersky [Canada] ; N. Labell [Canada] ; B. N. J. Growdon [États-Unis] ; C. Singer [États-Unis] ; R. Watts [États-Unis] ; S. Goldwurm [Italie] ; G. Pezzoli [Italie] ; K. B. Baker [États-Unis] ; M. L. Giroux [États-Unis] ; P. P. Pramstaller [Italie] ; D. J. Burn [Royaume-Uni] ; P. Chinnery [Royaume-Uni] ; S. Sherman [États-Unis] ; P. Vieregge [Allemagne] ; I. Litvan [États-Unis] ; J. F. Gusella [États-Unis] ; R. H. Myers [États-Unis] ; A. Parsian [États-Unis]Source :
- Neurology [ 0028-3878 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.
Affiliations:
- Allemagne, Australie, Canada, Italie, Royaume-Uni, États-Unis
- Alberta, Californie, Massachusetts, Missouri (État), Ontario
- Boston, Calgary, Los Angeles, Saint-Louis (Missouri), Toronto
- Université Washington de Saint-Louis, Université de Calgary, Université de Californie du Sud, Université de Toronto, École de médecine (Université Washington de Saint-Louis)
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Le document en format XML
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Racette</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>Saint Louis, MO</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. 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Tobin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Williamson, J" sort="Williamson, J" uniqKey="Williamson J" first="J." last="Williamson">J. Williamson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1><s3>CAN</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Labell, N" sort="Labell, N" uniqKey="Labell N" first="N." last="Labell">N. Labell</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1><s3>CAN</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Growdon, B N J" sort="Growdon, B N J" uniqKey="Growdon B" first="B. N. J." last="Growdon">B. N. J. Growdon</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>21 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, University of Miami</s1><s2>FL</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Emory University</s1><s2>Atlanta, GA;</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, GA;</wicri:noRegion></affiliation></author><author><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S." last="Goldwurm">S. Goldwurm</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Medical Genetics Unit, Istituti Clinici di Perfezionamento</s1><s2>Milano</s2><s3>ITA</s3><sZ>24 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G." last="Pezzoli">G. Pezzoli</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1><s2>Milano</s2><s3>ITA</s3><sZ>25 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Baker, K B" sort="Baker, K B" uniqKey="Baker K" first="K. B." last="Baker">K. B. Baker</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>OH</s2><s3>USA</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>OH</wicri:noRegion></affiliation></author><author><name sortKey="Giroux, M L" sort="Giroux, M L" uniqKey="Giroux M" first="M. L." last="Giroux">M. L. Giroux</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>OH</s2><s3>USA</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>OH</wicri:noRegion></affiliation></author><author><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Neu rology, General Regional Hospital Bolzano</s1><s3>ITA</s3><sZ>28 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Department of Neu rology, General Regional Hospital Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Chinnery, P" sort="Chinnery, P" uniqKey="Chinnery P" first="P." last="Chinnery">P. Chinnery</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Sherman, S" sort="Sherman, S" uniqKey="Sherman S" first="S." last="Sherman">S. Sherman</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Department of Neurology, University of Arizona</s1><s2>Tucson</s2><s3>USA</s3><sZ>31 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Tucson</wicri:noRegion></affiliation></author><author><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Klinik fur Neurologie, Klinikum Lippe-Lemgo</s1><s2>Lemgo</s2><s3>DEU</s3><sZ>32 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lemgo</wicri:noRegion><wicri:noRegion>Klinikum Lippe-Lemgo</wicri:noRegion><wicri:noRegion>Lemgo</wicri:noRegion></affiliation></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Department of Neurology, University of Louisville School of Medicine</s1><s2>KY</s2><s3>USA</s3><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>KY</wicri:noRegion></affiliation></author><author><name sortKey="Gusella, J F" sort="Gusella, J F" uniqKey="Gusella J" first="J. F." last="Gusella">J. F. Gusella</name><affiliation wicri:level="3"><inist:fA14 i1="23"><s1>Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>34 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Parsian, A" sort="Parsian, A" uniqKey="Parsian A" first="A." last="Parsian">A. Parsian</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences</s1><s2>Little Rock</s2><s3>USA</s3><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Little Rock</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0054738</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 06-0054738 INIST</idno><idno type="RBID">Pascal:06-0054738</idno><idno type="wicri:Area/PascalFrancis/Corpus">000871</idno><idno type="wicri:Area/PascalFrancis/Curation">000452</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000819</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000819</idno><idno type="wicri:doubleKey">0028-3878:2005:Karamohamed S:bdnf:genetic:variants</idno><idno type="wicri:Area/Main/Merge">002E87</idno><idno type="wicri:Area/Main/Curation">002B47</idno><idno type="wicri:Area/Main/Exploration">002B47</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study</title><author><name sortKey="Karamohamed, S" sort="Karamohamed, S" uniqKey="Karamohamed S" first="S." last="Karamohamed">S. Karamohamed</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Latourelle, J C" sort="Latourelle, J C" uniqKey="Latourelle J" first="J. C." last="Latourelle">J. C. Latourelle</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Racette, B A" sort="Racette, B A" uniqKey="Racette B" first="B. A." last="Racette">B. A. Racette</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>Saint Louis, MO</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. Perlmutter</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>Saint Louis, MO</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Wooten, G F" sort="Wooten, G F" uniqKey="Wooten G" first="G. F." last="Wooten">G. F. Wooten</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Virginia Health System</s1><s2>Charlottesville</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville</wicri:noRegion></affiliation></author><author><name sortKey="Lew, M" sort="Lew, M" uniqKey="Lew M" first="M." last="Lew">M. Lew</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>De partment of Neurology, University of Southern California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Medical University of Lübeck</s1><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Medical University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Neurology, Medical University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Shill, H" sort="Shill, H" uniqKey="Shill H" first="H." last="Shill">H. Shill</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Muhammad Ali Parkinson Research Center, Barrow Neurological Institute</s1><s2>Phoenix, AZ</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Phoenix, AZ</wicri:noRegion></affiliation></author><author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School</s1><s2>New Brunswick</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Brunswick</wicri:noRegion></affiliation></author><author><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School</s1><s2>New Brunswick</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Brunswick</wicri:noRegion></affiliation></author><author><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Medicine, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Nicholson, G" sort="Nicholson, G" uniqKey="Nicholson G" first="G." last="Nicholson">G. Nicholson</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital</s1><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Wilk, J B" sort="Wilk, J B" uniqKey="Wilk J" first="J. B." last="Wilk">J. B. Wilk</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Saint Hilaire, M" sort="Saint Hilaire, M" uniqKey="Saint Hilaire M" first="M." last="Saint-Hilaire">M. Saint-Hilaire</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A. L." last="Destefano">A. L. Destefano</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s2>MA</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>MA</wicri:noRegion></affiliation></author><author><name sortKey="Prakash, R" sort="Prakash, R" uniqKey="Prakash R" first="R." last="Prakash">R. Prakash</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Tobin, S" sort="Tobin, S" uniqKey="Tobin S" first="S." last="Tobin">S. Tobin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Williamson, J" sort="Williamson, J" uniqKey="Williamson J" first="J." last="Williamson">J. Williamson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1><s3>CAN</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Labell, N" sort="Labell, N" uniqKey="Labell N" first="N." last="Labell">N. Labell</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1><s3>CAN</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Growdon, B N J" sort="Growdon, B N J" uniqKey="Growdon B" first="B. N. J." last="Growdon">B. N. J. Growdon</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>21 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, University of Miami</s1><s2>FL</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Emory University</s1><s2>Atlanta, GA;</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, GA;</wicri:noRegion></affiliation></author><author><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S." last="Goldwurm">S. Goldwurm</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Medical Genetics Unit, Istituti Clinici di Perfezionamento</s1><s2>Milano</s2><s3>ITA</s3><sZ>24 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G." last="Pezzoli">G. Pezzoli</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1><s2>Milano</s2><s3>ITA</s3><sZ>25 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Baker, K B" sort="Baker, K B" uniqKey="Baker K" first="K. B." last="Baker">K. B. Baker</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>OH</s2><s3>USA</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>OH</wicri:noRegion></affiliation></author><author><name sortKey="Giroux, M L" sort="Giroux, M L" uniqKey="Giroux M" first="M. L." last="Giroux">M. L. Giroux</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>OH</s2><s3>USA</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>OH</wicri:noRegion></affiliation></author><author><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Neu rology, General Regional Hospital Bolzano</s1><s3>ITA</s3><sZ>28 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Department of Neu rology, General Regional Hospital Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Chinnery, P" sort="Chinnery, P" uniqKey="Chinnery P" first="P." last="Chinnery">P. Chinnery</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Sherman, S" sort="Sherman, S" uniqKey="Sherman S" first="S." last="Sherman">S. Sherman</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Department of Neurology, University of Arizona</s1><s2>Tucson</s2><s3>USA</s3><sZ>31 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Tucson</wicri:noRegion></affiliation></author><author><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Klinik fur Neurologie, Klinikum Lippe-Lemgo</s1><s2>Lemgo</s2><s3>DEU</s3><sZ>32 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lemgo</wicri:noRegion><wicri:noRegion>Klinikum Lippe-Lemgo</wicri:noRegion><wicri:noRegion>Lemgo</wicri:noRegion></affiliation></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Department of Neurology, University of Louisville School of Medicine</s1><s2>KY</s2><s3>USA</s3><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>KY</wicri:noRegion></affiliation></author><author><name sortKey="Gusella, J F" sort="Gusella, J F" uniqKey="Gusella J" first="J. F." last="Gusella">J. F. Gusella</name><affiliation wicri:level="3"><inist:fA14 i1="23"><s1>Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>34 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Boston University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Parsian, A" sort="Parsian, A" uniqKey="Parsian A" first="A." last="Parsian">A. Parsian</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences</s1><s2>Little Rock</s2><s3>USA</s3><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Little Rock</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of onset</term><term>Familial disease</term><term>Genetic variant</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Variant génétique</term><term>Age apparition</term><term>Maladie familiale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Alberta</li><li>Californie</li><li>Massachusetts</li><li>Missouri (État)</li><li>Ontario</li></region><settlement><li>Boston</li><li>Calgary</li><li>Los Angeles</li><li>Saint-Louis (Missouri)</li><li>Toronto</li></settlement><orgName><li>Université Washington de Saint-Louis</li><li>Université de Calgary</li><li>Université de Californie du Sud</li><li>Université de Toronto</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Karamohamed, S" sort="Karamohamed, S" uniqKey="Karamohamed S" first="S." last="Karamohamed">S. Karamohamed</name></noRegion><name sortKey="Baker, K B" sort="Baker, K B" uniqKey="Baker K" first="K. B." last="Baker">K. B. Baker</name><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A. L." last="Destefano">A. L. Destefano</name><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A. L." last="Destefano">A. L. Destefano</name><name sortKey="Giroux, M L" sort="Giroux, M L" uniqKey="Giroux M" first="M. L." last="Giroux">M. L. Giroux</name><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name><name sortKey="Growdon, B N J" sort="Growdon, B N J" uniqKey="Growdon B" first="B. N. J." last="Growdon">B. N. J. Growdon</name><name sortKey="Gusella, J F" sort="Gusella, J F" uniqKey="Gusella J" first="J. F." last="Gusella">J. F. Gusella</name><name sortKey="Latourelle, J C" sort="Latourelle, J C" uniqKey="Latourelle J" first="J. C." last="Latourelle">J. C. Latourelle</name><name sortKey="Lew, M" sort="Lew, M" uniqKey="Lew M" first="M." last="Lew">M. Lew</name><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name><name sortKey="Parsian, A" sort="Parsian, A" uniqKey="Parsian A" first="A." last="Parsian">A. Parsian</name><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. Perlmutter</name><name sortKey="Prakash, R" sort="Prakash, R" uniqKey="Prakash R" first="R." last="Prakash">R. Prakash</name><name sortKey="Racette, B A" sort="Racette, B A" uniqKey="Racette B" first="B. A." last="Racette">B. A. Racette</name><name sortKey="Saint Hilaire, M" sort="Saint Hilaire, M" uniqKey="Saint Hilaire M" first="M." last="Saint-Hilaire">M. Saint-Hilaire</name><name sortKey="Sherman, S" sort="Sherman, S" uniqKey="Sherman S" first="S." last="Sherman">S. Sherman</name><name sortKey="Shill, H" sort="Shill, H" uniqKey="Shill H" first="H." last="Shill">H. Shill</name><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name><name sortKey="Tobin, S" sort="Tobin, S" uniqKey="Tobin S" first="S." last="Tobin">S. Tobin</name><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name><name sortKey="Wilk, J B" sort="Wilk, J B" uniqKey="Wilk J" first="J. B." last="Wilk">J. B. Wilk</name><name sortKey="Williamson, J" sort="Williamson, J" uniqKey="Williamson J" first="J." last="Williamson">J. Williamson</name><name sortKey="Wooten, G F" sort="Wooten, G F" uniqKey="Wooten G" first="G. F." last="Wooten">G. F. Wooten</name></country><country name="Allemagne"><noRegion><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name></noRegion><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name></country><country name="Canada"><region name="Ontario"><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name></region><name sortKey="Labell, N" sort="Labell, N" uniqKey="Labell N" first="N." last="Labell">N. Labell</name><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name></country><country name="Australie"><noRegion><name sortKey="Nicholson, G" sort="Nicholson, G" uniqKey="Nicholson G" first="G." last="Nicholson">G. Nicholson</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S." last="Goldwurm">S. Goldwurm</name></noRegion><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G." last="Pezzoli">G. Pezzoli</name><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name></noRegion><name sortKey="Chinnery, P" sort="Chinnery, P" uniqKey="Chinnery P" first="P." last="Chinnery">P. Chinnery</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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